On January 6, 2017, the National Academy of Medicine (NAM) hosted the first meeting of the Action Collaborative on Clinician Well-Being and Resilience, chaired by NAM president Victor Dzau and co-chaired by AAMC president and CEO Darrell Kirch and ACGME CEO Thomas Nasca. Launched in response to alarming rates of burnout and suicide across the health care workforce, the Collaborative will work to advance clinician well-being as a national priority and generate evidence-based solutions for progress at both individual and systems levels. At the January meeting, more than 50 representatives from professional associations, health care organizations, government, insurers, academia, nonprofits, and other sectors gathered to share information and determine a framework for action. U.S. Surgeon General Vivek Murthy delivered remarks highlighting the importance of clinician well-being to the overall health of the nation and indicated his support for the ongoing work of the Collaborative. Although the group is still in its initial planning stage, future activities will include public workshops to engage more stakeholders and the creation of a knowledge hub of resources, among other activities. Future workshops and stakeholder events will be open to the public.